AJI-214 - CAS 1395886-20-0

AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD) .

JAK, Aurora Kinase, STAT

Cell Cycle/Checkpoint, Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Angiogenesis, Tyrosine Kinase/Adaptors

1395866

C17H13ClFN5O

357.77

O=C(N)C1=CC=C(C=C1)NC2=NC=C(F)C(=N2)NC=3C=CC=CC3Cl

-20°C

Ice Packs

Small Compound