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Molfinity

AKB-6899 - CAS 1007377-55-0

AKB-6899 - CAS 1007377-55-0

MF-0062374-01

$40.65 USD
$40.65 USD
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Product Details

  • Bioactivity

    AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.

  • Target

    HIF/HIF Prolyl-Hydroxylase, VEGFR, HIF

  • Related Pathways

    Chromatin/Epigenetic, Angiogenesis, Metabolism, Tyrosine Kinase/Adaptors

  • CAS Number

    1007322

  • Purity

    0.9787

  • Molecular Formula

    C14H11FN2O4

  • Molecular Weight

    290.25

  • SMILES

    OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound