AKR1C3-IN-15 - CAS 3059671-44-9

AKR1C3-IN-15 (compound 30) is an effective and selective AKR1C3 inhibitor with an IC50 value of 5 nM. It enhances Sorafenib-induced ROS production, promotes apoptosis, and restores sensitivity to Sorafenib in hepatocellular carcinoma (HCC) models, as demonstrated in both in vitro and in vivo studies.

Reductase, Apoptosis

Metabolism, Endocrinology/Hormones, Apoptosis

3059618

C19H16FNO4

341.33

O=C(O)C1=CC=C(C=C1)CN(C(=O)C2=CC=3C=CC(F)=CC3OC2)C

-20°C

Ice Packs

Small Compound