AKT-IN-25 - CAS 1619929-59-7

AKT-IN-25 (Compound 14a) is an inhibitor of Akt that prevents the phosphorylation of Akt, thereby hindering the PI3K/Akt/mTOR signaling pathway. It arrests the cell cycle at the G1 phase, inhibits the migration of PANC-1 cells, and suppresses the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2, with IC50 values of 3.05, 1.32, and 3.85 μM, respectively.

Akt

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

1619863

C14H16N4O

256.3

O=C(N1N=NC(=C1)C=2C=CC=CC2)N3CCCCC3

-20°C

Ice Packs

Small Compound