Akt1-IN-8 - CAS 2247688-87-3

Akt1-IN-8 (Compound JL18) is a potent AKT1 kinase inhibitor with oral bioavailability of 41% and an IC50 value of 8.8 nM. It exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 also reduces phosphorylated GSK3β levels.

Akt

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

2247598

C21H25Br2N7O

551.278

O=C(N1CCN(C=2N=CN=C3NN=C(Br)C32)CC1)C(C4=CC=C(Br)C=C4)CNC(C)C

-20°C

Ice Packs

Small Compound