AKV-9 - CAS 1307262-15-2

AKV-9 is an inhibitor of mutant Cu/Zn superoxide dismutase (SOD1), effectively preventing SOD1-induced protein aggregation and providing protection against SOD1-induced cytotoxicity in PC-12 cells, with an EC50 of 0.3 μM. Additionally, AKV-9 has been shown to improve amyotrophic lateral sclerosis (ALS) in mouse models and extend their lifespan.

Others

Others

1307245

C16H14F6O3

368.27

C(F)(F)(F)C1=CC(C(F)(F)F)=CC(O[C@@H](C)C2CC(=O)CC(=O)C2)=C1

-20°C

Ice Packs

Small Compound