Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 - CAS 211190-38-4

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1) [a subtype of G-protein coupled receptors involved in mediating thrombin's cellular effects]. Exhibiting high specificity for PAR-1 over PAR-2, its selectivity was assessed via cell-based calcium signaling assays in HEK293 cells. As an agonist, it is instrumental for in vivo investigations of PAR-1 activation. PAR-1 also collaborates with PAR-4, influencing thrombin-induced hepatocellular carcinoma within [coagulation type] tumor environments where thrombin generation occurs.

Protease-activated Receptor

GPCR/G Protein

211148

C42H63FN12O8

883.02

[C@@H](CC1CCCCC1)(NC([C@@H](NC([C@H](CC2=CC=C(F)C=C2)NC([C@H](C)N)=O)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N)=O)=O)CCCNC(N)=O)=O

-20°C

Ice Packs

Peptide