ALG-097558 - CAS 2892287-29-3

ALG-097558 is an orally active 3CL protease inhibitor. It demonstrates broad antiviral activity against various SARS-CoV-2 variants and other human coronaviruses, including SARS-CoV-1, α-HCoV 229E, and β-HCoV OC43. ALG-097558 exhibits potent inhibitory effects, with an IC50 of 2 nM for SARS-CoV-2 3CL protease and 6 nM for 229E 3CL protease. In a SARS-CoV-2 hamster infection model, ALG-097558 shows antiviral activity and can be used for research on viral infections.

SARS-CoV, Virus Protease

Microbiology/Virology

2892255

C25H32ClF2N5O4

540

C(N[C@@H](C[C@H]1C(=O)NCC1)C#N)(=O)[C@@H]2[C@@]3([C@@]([C@]4(C[C@@]3(C=C4)[H])[H])(CN2C([C@@H](NC(C(Cl)(F)F)=O)[C@](C)(C)C)=O)[H])[H]

-20°C

Ice Packs

Small Compound