ALK/EGFR-IN-1 - CAS 2730430-08-5

ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation. It demonstrates potent inhibition of ALK/EGFR mutants with IC50 values of 4.3 nM for EGFR L858R T790M in H1975 cells and 3.6 nM for EML4-ALK in BaF3 cells. This compound may be applicable in the research of non-small cell lung cancer (NSCLC) [1].

EGFR, Apoptosis, ALK

Apoptosis, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

2730430-08-5

C27H34ClN7O3S

572.12

N(CCN(C)C)(C)C1=C(NC(C=C)=O)C=C(NC=2N=C(NC3=C(S(CC)=O)C=CC=C3)C(Cl)=CN2)C(OC)=C1

-20°C

Ice Packs

Small Compound