ALK-IN-31 - CAS 3043840-25-8

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC) .

ALK, Apoptosis, Akt, mTOR

Angiogenesis, Apoptosis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

3043807

C30H33N5O2S

527.68

O=C1C2=CC=C(C=C2CCC1)NC=3N=C(NC=4C=CC=CC4NC(=O)C5CCCCC5)C6=C(N3)CCSC6

-20°C

Ice Packs

Small Compound