ALK5-IN-82 - CAS 3001361-04-9

ALK5-IN-82 is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), demonstrating an IC50 value of 9.1 nM. This compound effectively suppresses the expression of α-smooth muscle actin (α-SMA), collagen I, and the proteinases tissue inhibitor of metalloproteinase 1 (TIMP-1) and matrix metalloproteinase 13 (MMP-13) in human umbilical vein endothelial cells induced by transforming growth factor-β. ALK5-IN-82 shows potential for use in research related to cardiac fibrosis.

TGF-beta/Smad, Others

Stem Cells, Others

3001361-04-9

C22H19N7OS

429.5

O=C(NCC1=NC(C2=NC(=CC=C2)C)=C(N1)C=3C=CC4=NC=NN4C3)CC=5SC=CC5

-20°C

Ice Packs

Small Compound