Alloc-Val-Ala-pAB - CAS 1343407-91-9

Alloc-Val-Ala-PAB is a cleavable peptide linker employed in the synthesis of antibody-drug conjugates (ADC) . The Val-Ala sequence is specifically cleaved by cathepsin B. The Alloc group remains stable when treated with piperidine and TFA, yet it can be easily removed under mild conditions via palladium-catalyzed allyl transfer.

ADC Linker

Antibody-drug Conjugate/ADC Related

1343407-91-9

C19H27N3O5

377.435

N(C([C@@H](NC([C@@H](NC(OCC=C)=O)[C@@H](C)C)=O)C)=O)C1=CC=C(CO)C=C1

-20°C

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