Aloenin aglycone - CAS 59163-53-0

Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate. It impedes TNFα-stimulated NF-κB transcriptional activity, showing an IC 50 of 18.7 μM. At a concentration of 10 μM, aloenin aglycone decreases both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression in HepG2 cells exposed to 10 ng/mL TNFα [1].

NO Synthase, Others, NF-κB

Immunology/Inflammation, NF-κB, Others

59110

C13H12O5

248.23

CC1=C(C(O)=CC(O)=C1)C2=CC(OC)=CC(=O)O2

-20°C

Ice Packs

Natural Product