Alrizomadlin - CAS 1818393-16-6

Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines. The IC50 values ​​are 26.8 nM for MOLM-13 cells and 165.9 nM for MV-4-11 cells. , OCI-AML-3 cells 315.6 nM. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53-dependent manner.

MDM-2/p53, E1/E2/E3 Enzyme, Mdm2, Apoptosis

Apoptosis, Ubiquitination

1818393-16-6

0.9947

C34H38Cl2FN3O4

642.59

CCN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)C(=O)NC12CCC(CC1)(CC2)C(O)=O

-20°C

Ice Packs

Small Compound