Alvimopan - CAS 156053-89-3

Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4- (3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.

Opioid Receptor

GPCR/G Protein, Neuroscience, Endocrinology/Hormones

155961

0.9997

C25H32N2O4

424.53

C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(O)=O)CC[C@@]1(C)c1cccc(O)c1

-20°C

Ice Packs

Small Compound