AM-0687 - CAS 1259522-94-5

AM-0687 is a potent and selective PI3Kδ inhibitor. AM-0687 has Cellular potency: pAKT IC50 = 0.7 nM; HWB, u (pAKT) IC 50 = 4.6 nM. Rat KLH: IgG ED50 -= 0.026 mg/kg; IgM ED50 = 0.016 mg/kg. Rat PK Clu = 2.3 L/hr/kg.

Others, PI3K

Others, PI3K/Akt/mTOR signaling

1259423

C23H19FN8O

442.45

C(NC)(=O)C1=C(C([C@@H](NC=2C(C#N)=C(N)N=CN2)C)=NC3=C1C=C(F)C=C3)C4=CC=CC=N4

-20°C

Ice Packs

Small Compound