AM-3189 - CAS 916219-50-6

AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavailability. AM-3189 does not penetrate the rat CNS as indicated by a rat brain to plasma ratio of 0.04 at 3 h after an oral dose of 5 mg/kg.

Others

Others

916163

C27H25ClN2O3

460.95

[C@H](CC(O)=O)(C1=CC=C(OCC2=CC(=CC=C2)C3=C(C)C=C(Cl)C=C3)C=C1)C=4N(C)C=CN4

-20°C

Ice Packs

Small Compound