AM-8508 - CAS 1338483-67-2

AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM) . AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM) . AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.

Others

Others

1338414

C19H15FN8

374.37

[C@H](NC=1C(C#N)=C(N)N=CN1)(C)C=2N(C=3C(N2)=CC=C(F)C3)C=4C=CC=NC4

-20°C

Ice Packs

Small Compound