AM679 - CAS 1206880-66-1

AM679 is a potent and selective FLAP inhibitor with IC50 values of 2.2 nM (FLAP binding), 0.6 nM (hLA), and 154 nM (hWB) . AM679 displays improved CYP inhibition characteristics, no CYP3A4 time-dependent inhibition or induction, and strong in vivo leukotriene inhibition in rodent BAL models after oral administration.

Cytochromes P450, LTR, FLAP

Metabolism, Immunology/Inflammation

1206813

0.9945

C40H44N4O5S

692.87

C(N1C=2C(C(SC(C)(C)C)=C1CC(C(O)=O)(C)C)=CC(OC[C@H]3N(C(C)=O)C=4C(C3)=CC=CC4)=CC2)C5=CC=C(C=C5)C=6N=CC(OC)=CN6

-20°C

Ice Packs

Small Compound