AMD 3465 - CAS 185991-24-6

AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM) . However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.

HIV Protease, CXCR

Immunology/Inflammation, Proteases/Proteasome, Microbiology/Virology, GPCR/G Protein, Autophagy

185961

C24H38N6

410.6

N=1C=CC=CC1CNCC2=CC=C(C=C2)CN3CCNCCCNCCNCCC3

-20°C

Ice Packs

Small Compound