AMG 21629 - CAS 939040-79-6

Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors and acid-induced Ca2+ uptake, respectively) . Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

Others, TRP/TRPV Channel

Membrane transporter/Ion channel, Others

938955

C22H19F3N6O3

472.42

O(C1=C2C(NC(=O)C(N)=N2)=CC=C1)C=3C=C(N=C(NCCOC)N3)C4=CC=C(C(F)(F)F)C=C4

-20°C

Ice Packs

Small Compound