AMG-548 - CAS 864249-60-5

AMG-548 is a selective and orally active p38α MAPK inhibitor (Ki = 0.5 nM), with higher selectivity than p38β, p38γ, and p38δ, and can also inhibit the TNFα, CK1δ/ε, and Wnt signalling pathways.

Casein Kinase, p38 MAPK, Wnt/beta-catenin, TNF

MAPK, Metabolism, Apoptosis, Stem Cells, Cytoskeletal Signaling

864184

0.9991

C29H27N5O

461.56

O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5

-20°C

Ice Packs

Small Compound