AMG-628, (R) - - CAS 862269-93-0

AMG-628, (R) - is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.

Others, TRP/TRPV Channel

Others, Membrane transporter/Ion channel

862176

C25H25FN6O2S

492.57

C[C@@H](N1CCN(CC1)C1=CC(OC2=C3N=C(NC(C)=O)SC3=CC=C2)=NC=N1)C1=CC=C(F)C=C1

-20°C

Ice Packs

Small Compound