(Aminooxy) acetamide-Val-Cit-PAB-MMAE - CAS 2446645-88-9

(Aminooxy) acetamide-Val-Cit-PAB-MMAE (MMAE 5) serves as an intermediate for synthesizing drug-linker conjugates in antibody-drug conjugates (ADCs) . The compound is initially conjugated to a polyamide via oxime bond formation, forming an MMAE polyamide conjugate, which is then attached to Trastuzumab to create the ADC [1].

Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related

2446548

C60H97N11O14

1196.48

[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC(CON)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]

-20°C

Ice Packs

Small Compound