Amycolatopsin A - CAS 2209112-96-7

Amycolatopsin A is a macrolide polyketide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis (IC50s = 0.4 and 4.4 μM, respectively) but notB. subtilis, S. aureus, E. coli, orP. aeruginosa (IC50s = >30 μM for all) . Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 μM, respectively) .

Antibacterial, Others

Others, Microbiology/Virology

2209009

C60H98O23

1187.421

COCCC[C@H]1O[C@@](O)([C@@H](C)C2CC(OC)C(O)\C=C(\C)/C=C(\C)/C=C(C)/C(O[C@H]3O[C@H](C)[C@@H](OC)[C@H](O)[C@H]3O)C(C)\C=C(/CO)\C=C(/OC)\C=C(C)\C(=O)O2)[C@H](OC)[C@@H](O)[C@]1(C)O[C@H]1C[C@H](O)[C@H](O[C@H]2C[C@@](C)(O)[C@H](O)[C@@H](C)O2)[C@@H](C)O1

-20°C

Ice Packs

Small Compound