Amyloid-β-IN-3 - CAS 1603833-56-2

Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.

Beta Amyloid, Gamma-secretase

Neuroscience, Proteases/Proteasome, Stem Cells

1603775

C22H21F2N3O2

397.42

C(NC1=CC(F)=CC(F)=C1)(=O)C2=CC=3C(N2)=CC=C(C3)[C@H]4CN(C(C)=O)CCC4

-20°C

Ice Packs

Small Compound