Anemoside A3-methyl 6-aminohexanoate - CAS 2919975-48-5

Anemoside A3-methyl 6-aminohexanoate (Compound A3-6), a derivative of Pulchinenoside C (Anemoside B4), exhibits potent inhibition of pyruvate carboxylase (PC) with an IC 50 of 0.058 μM. It also reprograms macrophage function and alleviates DSS-induced colitis by inhibiting the NF-κB and NLRP3 inflammasome pathways. Compared to Anemoside B4, Anemoside A3-methyl 6-aminohexanoate demonstrates moderate in vivo pharmacokinetic properties.

NF-κB

NF-κB

2919975-48-5

C48H79NO13

878.14

C(NCCCCCC(OC)=O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)([C@@](CO)(C)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@@H](O)CO6)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

-20°C

Ice Packs

Small Compound