Anti-infective agent 9 - CAS 758689-17-7

Anti-infective agent 9 (compound 1) acts as a Plasmodium falciparum inhibitor, demonstrating an IC 50 of 600 nM. It effectively reduces pyruvate levels and disrupts the TCA cycle within Plasmodium. This compound also exhibits robust metabolic stability and minimal toxicity to human liver cells. Research indicates that the potential targets of Anti-infective agent 9 for inhibiting Plasmodium falciparum do not include 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) [1].

Parasite

Microbiology/Virology

758689-17-7

C14H11F3N4S2

356.39

FC(F)(F)C1=CC=C(C=C1)NC2=NC(=CS2)C=3SC(=NC3C)N

-20°C

Ice Packs

Small Compound