Anti-inflammatory agent 54 - CAS 2924156-46-5

Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-α, IL-6, and IL-1β. It effectively suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates in vivo efficacy in a mouse auricular edema model [1].

NF-κB, Others, Interleukin, NO Synthase, TNF

Apoptosis, NF-κB, Others, Immunology/Inflammation

2924105

C17H16N2O5

328.32

C(CNC(/C=C/C1=CC=CO1)=O)N2C=3C(OC2=O)=CC(OC)=CC3

-20°C

Ice Packs

Small Compound