Anti-inflammatory agent 56 - CAS 2413127-32-7

Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits antioxidant and anti-inflammatory properties by inhibiting oxidative stress-induced cell death and neuroinflammation through the suppression of Keap1, COX-2, and iNOS. It demonstrates low acute toxicity in mice with an LD50 of 1000 mg/kg [1].

COX

Immunology/Inflammation, Neuroscience

2413088

C21H15F3N4O4S

476.43

OC1=C(C=2N(N=C(N2)C3=C(O)C=C(C(F)(F)F)C=C3)C4=CC=C(S(N)(=O)=O)C=C4)C=CC=C1

-20°C

Ice Packs

Small Compound