Antibiofilm agent-12 - CAS 480452-24-2

Antibiofilm agent-12 (Compound C13), an antifungal belonging to the carbamate derivatives, exhibits significant antifungal activity against Candida auris, with an MIC90 of 237.9 μM. It inhibits the drug efflux pump activity of Candida auris and promotes ergosterol depletion, thereby hindering the formation of Candida auris biofilms and reducing its metabolic flexibility. Additionally, Antibiofilm agent-12 demonstrates antifungal efficacy in a C. elegans model following Candida auris infection.

Antifungal

Microbiology/Virology

480426

C13H11ClN2O2

262.69

O=C(OC=1C=CC=CC1)NNC2=CC=C(Cl)C=C2

-20°C

Ice Packs

Small Compound