Antibiotic PF 1052 - CAS 147317-15-5

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 μM.

Antifungal, Others, Antibiotic, Antibacterial

Others, Microbiology/Virology

147297

C26H39NO4

429.601

CCC(C)C1N(C)C(=O)C(=C(O)C2C(C=CC3CC(C)CC(C)C23)C2(C)OC2C)C1=O |w:10.10,c:14|

-20°C

Ice Packs

Natural Product