Anticancer agent 147 - CAS 2241283-11-2

Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), enhances endoplasmic reticulum (ER) stress, and upregulates activating transcription factor 3 (ATF3) expression, demonstrating potent anti-liver cancer effects both in vitro and in vivo [1].

Ferroptosis

Apoptosis

2241270

C32H40BrN3O2

578.58

C(CCC(OC)=O)[C@@H]1[C@@]2([C@@]3([C@@](CN1CC=4C=5C(N(CC6=CC=C(Br)C=C6)C4)=CC=CC5)(CCCN3CCC2)[H])[H])[H]

-20°C

Ice Packs

Small Compound