Anticancer agent 82 - CAS 2319587-80-7

Anticancer agent 82 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Anticancer agent 82 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 [1].

Others, Proteasome

Others, Proteases/Proteasome, Ubiquitination

2319500

C19H18Cl2N4O

389.28

COc1cc(Cl)cc(c1)N1CCN(CC1)c1cnnc2c(Cl)cccc12

-20°C

Ice Packs

Small Compound