Antifolate agent 1 - CAS 518063-75-7

Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.

Antifolate

Cell Cycle/Checkpoint

517981

C19H19N5O6

413.38

O=C1C2=C(NC(CC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)NC(N)=N1

-20°C

Ice Packs

Small Compound