Antiproliferative agent-30 - CAS 2713553-88-7

Antiproliferative agent-30 (Compound 8g) exhibits broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It inhibits tubulin assembly, FLT3, and Abl1 kinases and shows vascular-disrupting capabilities. Additionally, it displays an anticancer effect against acute myeloid leukemia (AML) with FLT3-ITD-TKD mutations [1].

Microtubule Associated, FLT, Others, Bcr-Abl

Tyrosine Kinase/Adaptors, Angiogenesis, Cytoskeletal Signaling, Others

2713458

C24H26N4O4

434.49

O(C)C=1C=C(C=2C=3C(NN2)=NC=C(C3)C4=CC(NCCO)=C(C)C=C4)C=C(OC)C1OC

-20°C

Ice Packs

Small Compound