Antiproliferative agent-34 - CAS 2910858-34-1

Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT. Additionally, it inhibits JAK2, ROS1, FLT3, FLT4, and PDGFRα with respective IC50s of 30.93 nM, 106.90 nM, 108.00 nM, 226.60 nM, and 42.53 nM. In normoxic conditions, it suppresses the proliferation of H1975 and HCC827 cells with IC50 values below 40 nM, while under hypoxic conditions, its potency increases 4-6 fold, yielding IC50 values less than 10 nM [1].

EGFR

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling

2910823

C27H27N7O5

529.55

O=[N+](C1=NC=CN1CCOCCOC(C=C2NC3=NC=CC(C(C4=CC=CC=C45)=CN5C)=N3)=C(C=C2)OC)[O-]

-20°C

Ice Packs

Small Compound