Antiproliferative agent-64 - CAS 1139263-21-0

Antiproliferative agent-64 (Compound 76) functions as an inhibitor of the eukaryotic translation initiation factor 4E (eIF4E) and disrupts the secondary structure of mRNA, thereby hindering protein translation. It inhibits the 5' untranslated region (5'UTR) of c-Myc with an EC50 of 1.2 nM and the 5'UTR of tubulin with an EC50 of 40 nM. Additionally, Antiproliferative agent-64 suppresses the proliferation of MDA-MB-231 cells with an EC50 of 7 nM.

Microtubule Associated, DNA/RNA Synthesis

Cytoskeletal Signaling, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

1139242

C29H28N2O6

500.54

O[C@]12[C@]([C@@H]([C@@H](C(N(C)C)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(OC)C4)C5=CC=C(C#N)C=C5

-20°C

Ice Packs

Small Compound