Antisauvagine-30 - CAS 220673-95-0

Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively) . Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49) . Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.

CRFR

GPCR/G Protein

220578

C161H274N48O46S

3650.29

-20°C

Ice Packs

Peptide