Antitumor agent-61 - CAS 2408917-12-2

Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity with IC50 values ranging from 0.92 to 3.23 μM against six human cancer cell lines: SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549, and MG-63, and specifically induces apoptosis in SK-OV-3 cells via mitochondrial pathways [1].

Apoptosis, Others

Apoptosis, Others

2408903

C54H63FN5O10P

992.08

CCOP(=O)(OCC)C(Nc1ccc(CCCC(=O)OC2(CC)C(=O)OCc3c2cc2-c4nc5ccc(OC(=O)N6CCC(CC6)N6CCCCC6)cc5c(CC)c4Cn2c3=O)cc1)c1ccc(F)cc1

-20°C

Ice Packs

Small Compound