Antitumor agent-81 - CAS 2765180-17-2

Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.

Others, E1/E2/E3 Enzyme, p62, Apoptosis

Apoptosis, Autophagy, Others, Ubiquitination

2765161

C19H19N7O3

393.4

O(C)C=1C=C(N2C=C(N=N2)C3=CC4=C(C=C3)N=C(N)N=C4N)C=C(OC)C1OC

-20°C

Ice Packs

Small Compound