AP-1/NF-κB activation inhibitor 1 - CAS 188936-12-1

AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation (IC50 = 1 μM), without blocking basal transcription driven by the β-actin promoter. It has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells [1].

NF-κB, DNA/RNA Synthesis

NF-κB, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

188923

>99.99%

C13H11F3N4O4

344.25

CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)C(F)(F)F

-20°C

Ice Packs

Small Compound