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Molfinity

AP 18 - CAS 55224-94-7

AP 18 - CAS 55224-94-7

MF-0011745-01

$39.90 USD
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Product Details

  • Bioactivity

    AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA) -induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM) .

  • Target

    TRP/TRPV Channel

  • Related Pathways

    Membrane transporter/Ion channel

  • CAS Number

    55224-94-7

  • Purity

    0.9996

  • Molecular Formula

    C11H12ClNO

  • Molecular Weight

    209.67

  • SMILES

    C\C(=C/c1ccc(Cl)cc1)\C(\C)=N\O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound