Apalcillin - CAS 63469-19-2

Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone β-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 μg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 μg/mL) . However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220's effectiveness against certain extended-spectrum β-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type β-lactamases.

Antibacterial

Microbiology/Virology

63448

C25H23N5O6S

521.55

N(C([C@H](NC(=O)C1=C(O)C2=C(N=C1)C=CC=N2)C3=CC=CC=C3)=O)[C@H]4[C@@]5(N([C@@H](C(O)=O)C(C)(C)S5)C4=O)[H]

-20°C

Ice Packs

Small Compound