APD-94 - CAS 877810-03-2

APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.

Microtubule Associated, Apoptosis, BMI-1

Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Cytoskeletal Signaling

877810-03-2

C18H17N3O4

339.345

OC=1C=C(OC)C=CC1C2=NC(=NC=C2OC3=CC=CC(OC)=C3)N

-20°C

Ice Packs

Small Compound