APH02174 - CAS 3065494-66-5

APH02174 is a highly selective and orally active IRAK4PROTAC degrader, with a DC50 of 4.01 nM in THP-1 cells. It blocks inflammatory signaling by inhibiting IL-6 release and is applicable for researching inflammatory diseases such as psoriasis and rheumatoid arthritis.

IRAK, PROTACs, Interleukin

Immunology/Inflammation, PROTAC, NF-κB

3065423

C49H55N7O8

870

C(N1CCC2(CC=3C(O2)=CC(=C(NC(=O)C=4C=5C(OC4)=CC=CN5)C3)N6CCC(CO)CC6)CC1)[C@H]7CC[C@H](OCC#CC8=C9C(N(C(=O)N9C)C%10C(=O)NC(=O)CC%10)=CC=C8)CC7

-20°C

Ice Packs

PROTAC