Aphadilactone C - CAS 1522004-70-1

Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217) .

Parasite, Others, Acyltransferase

Microbiology/Virology, Metabolism, Others

1521933

C40H52O8

660.84

C\C(CCC[C@H]1CC[C@](CCC\C(C)=C\[C@@H]2CC(C)=CC(=O)O2)(C2=CC(=O)C(C)(C)O2)C2=C1OC(C)(C)C2=O)=C/[C@@H]1CC(C)=CC(=O)O1

-20°C

Ice Packs

Natural Product