API-1 - CAS 36707-00-3

API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .

Apoptosis, PARP, Caspase, Akt

Cytoskeletal Signaling, Proteases/Proteasome, Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

36707-00-3

0.9907

C13H15N5O6

337.29

NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c2c1=O

-20°C

Ice Packs

Small Compound