APJ receptor agonist 4 - CAS 2135515-67-0

APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.

Apelin receptor, Others

GPCR/G Protein, Others

2135448

C28H28ClFN6O3

551.02

CCc1cccc(CC)c1-n1c(O)c(C(=O)N2CCC(C2)c2ncc(Cl)cc2F)c(=O)nc1-c1ccn(C)n1

-20°C

Ice Packs

Small Compound