APJ receptor agonist 5 - CAS 2135514-20-2

APJ receptor agonist 5 (compound 3) is a potent and orally active apelin receptor (APJ) agonist (EC 50: 0.4 nM) with excellent pharmacokinetic profiles in rodent heart failure (HF) models and an acceptable safety profile in preclinical toxicology studies, improving cardiac function and useful for HF disease research.

Others, Apelin receptor

Others, GPCR/G Protein

2135492

C26H29N3O6

479.52

C(OCC)C=1N(C(O)=C(C(=O)N2C[C@H](CC2)C3=CC=CC=C3)C(=O)N1)C4=C(OC)C=CC=C4OC

-20°C

Ice Packs

Small Compound